LC Bead is a preformed, deformable microsphere consisting of a biocompatible, sulphonate-modified, N-Fil hydrogel.

LC Bead Features

• Calibrated size to ensure predictable embolization

• Compressible design for smooth catheter delivery

• Compatible with a large range of microcatheters

• Blue tinted beads for enhanced visualization

• Spherical shape for optimal control and delivery

LC Bead M1

70-150μm beads allow:

• Controlled distal embolization results in a more homogeneous distribution in the targeted tissue

• Greater likelihood of tumor necrosis

• Less opportunity for the development of collateral circulation

INDICATIONS

LC Bead M1 are intended to be used for the embolization of hypervascular tumors and arteriovenous malformations (AVMs).

CONTRAINDICATIONS

• Patients intolerant to occlusion procedures
• Vascular anatomy or blood flow that precludes catheter placement or emboli injection
• Presence or likely onset of vasospasm
• Presence or likely onset of hemorrhage
• Presence of severe atheromatous disease
• Presence of feeding arteries smaller than distal branches from which they emerge
• Presence of patent extra-to-intracranial anastomoses or shunts
• Presence of collateral vessel pathways potentially endangering normal territories during embolization
• Presence of end arteries leading directly to cranial nerves
• Presence of arteries supplying the lesion not large enough to accept LC Bead M1
• Vascular resistance peripheral to the feeding arteries precluding passage of LC Bead M1 into the lesion.

• Embolization of large diameter arteriovenous shunts (ie. where the blood does not pass through the arterial/capillary/venous transition but directly from artery to vein.
• The pulmonary arterial vasculature.
• Any vasculature where LC Bead M1 Embolic Agent could pass directly into the internal carotid artery or other nontarget territories.

WARNING

Studies have shown that LC Bead M1 do not form aggregates and, as a result, penetrate deeper into the vasculature as compared to similarly sized PVA particles. Care must be taken to choose a larger sized LC Bead M1 Embolic Agent when embolizing arteriovenous malformations with large shunts to avoid passage of the microspheres into the pulmonary or coronary circulation.

The color of the LC Bead M1 could be visible through the skin if injected into arteries feeding superficial tissues.

POTENTIAL COMPLICATIONS

• Undesirable reflux or passage of LC Bead M1 into normal arteries adjacent to the targeted lesion or through the lesion into other arteries or arterial beds, such as the internal carotid artery, pulmonary, or coronary circulations
• Non-target embolization
• Pulmonary embolization
• Ischemia at an undesirable location
• Capillary bed saturation and tissue damage
• Ischemic stroke or Ischemic infarction
• Vessel or lesion rupture and hemorrhage
• Neurological deficits including cranial nerve palsies
• Vasospasm
• Death
• Recanalization
• Foreign body reactions necessitating medical intervention
• Infection necessitating medical intervention
• Clot formation at the tip of the catheter and subsequent dislodgement.

LC Bead M1 is available in one size: 70-150μm
LC Bead is available in 3 sizes from 100μm to 500μm

* Theoretical calculation based on the average diameters of a normal distribution of beads in a vial.
1. Biocompatibles data on file.LC Bead and LC Bead M1 are only cleared by the FDA for the embolization of hypervascular tumors and arteriovenous malformations (AVMs)
When using LC Bead and LC Bead M1 you do not need to add Ethiodol®